![]() | ||
B*0801-β2MG with bound peptide1m05 | ||
major histocompatibility complex (human), class I, B8 | ||
Alleles | B*0801 | |
Structure (See HLA-B) | Avail. 3D structures | |
EBI-HLA | B*0801 | 1mi5, 1m05 1agf, 1age 1agd, 1agc 1agb,1a9b |
Symbol(s) | HLA-B | |
Locus | chr.6 6p21.31 |
HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products.[1] (For terminology help see: HLA-serotype tutorial) HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.
Serotype
editB*08 | B8 | Sample |
allele | % | size (N) |
*8101 | 99 | 6508 |
*0804 | 29 | 7 |
Allele links out to IMGT/HLA Databease at EBI |
Alleles
editfreq | ||
ref. | Population | (%) |
[3] | Ireland South | 18.2 |
[3] | Australia New South Wales | 17.3 |
[3] | Ireland Northern | 16.2 |
[3] | Belgium | 12.6 |
[3] | Oman | 11.0 |
[3] | Spain Basque Gipuzkoa Province | 9.1 |
[3] | Finland | 8.9 |
[3] | France South East | 8.9 |
[3] | Scotland Orkney | 8.8 |
[3] | Morocco Nador Metalsa Class I | 8.7 |
[3] | India New Delhi | 8.3 |
[3] | Spain Eastern Andalusia Gipsy | 8.1 |
[3] | Madeira | 7.8 |
[3] | Guinea Bissau | 7.7 |
[3] | Iran Baloch | 7.6 |
[3] | South African Natal Zulu | 7.5 |
[3] | Brazil Belo Horizonte | 7.4 |
[3] | Cape Verde Southeastern Islands | 7.3 |
[3] | Romanian | 7.3 |
[3] | Saudi Arabia Guraiat and Hail | 7.1 |
[3] | South Africa Natal Tamil | 7.1 |
[3] | Georgia Svaneti Svans | 6.9 |
[3] | India Andhra Pradesh Golla | 6.7 |
[3] | Portugal North | 6.5 |
[3] | Azores Santa Maria and Sao Miguel | 6.4 |
[3] | Uganda Kampala | 6.2 |
[3] | Cape Verde Northwestern Islands | 5.6 |
[3] | Cameroon Yaounde | 5.4 |
[3] | Italy Bergamo | 5.3 |
[3] | Czech Republic | 5.2 |
[3] | Cameroon Pygmy Baka | 5.0 |
[3] | Senegal Niokholo Mandenka | 4.8 |
[3] | Kenya Nandi | 4.6 |
[3] | Spain Catalonia Girona | 4.6 |
[3] | Tunisia | 4.6 |
[3] | Bulgaria Gipsy | 4.5 |
[3] | Tunisia Tunis | 4.5 |
[3] | Brazil | 4.3 |
[3] | Portugal Centre | 4.0 |
[3] | Sudanese | 4.0 |
[3] | Cameroon Sawa | 3.8 |
[3] | Jordan Amman | 3.8 |
[3] | Indig. Australian, Cape York Peninsula | 3.5 |
[3] | Georgia Tbilisi Kurds | 3.4 |
[3] | Zambia Lusaka | 3.4 |
[3] | Kenya | 3.1 |
[3] | Zimbabwe Harare Shona | 3.1 |
[3] | Kenya Luo | 3.0 |
[3] | Mexico Zaptotec Oaxaca | 3.0 |
[3] | India North Hindus | 2.9 |
[3] | Mexico Mestizos | 2.4 |
[3] | Ivory Coast Akan Adiopodoume | 2.3 |
[3] | Indig. Australian, Groote Eylandt | 2.0 |
[3] | Portugal South | 2.0 |
[3] | Georgia Tbilisi Georgians | 1.9 |
[3] | Azores Central Islands | 1.8 |
[3] | Bulgaria | 1.8 |
[3] | Argentina Toba Rosario | 1.7 |
[3] | Croatia | 1.7 |
[3] | India North Delhi | 1.6 |
[3] | China North Han | 1.4 |
[3] | Cameroon Beti | 1.1 |
[3] | Cameroon Bakola Pygmy | 1.0 |
[3] | India West Coast Parsis | 1.0 |
[3] | Taiwan Siraya | 1.0 |
References
edit- ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
- ^ derived from IMGT/HLA
- ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc bd be bf bg bh bi bj bk bl bm Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
🔥 Top keywords: Akademia e Shkencave e RPS te ShqiperiseAlexandria Ocasio-CortezBilderberg GroupCristiano RonaldoDong XiaowanMinecraftOperation GladioPrimal cutRiot FestStrictly Come Dancing (series 7)Main PageSpecial:SearchUEFA Euro 2024Wikipedia:Featured picturesJulian AssangeShifty ShellshockFlorida PanthersList of Stanley Cup championsUEFA European ChampionshipPaul MauriceConnor McDavidMatthew TkachukCleopatraDeaths in 2024House of the Dragon2024 ICC Men's T20 World CupKeith Tkachuk2024 Copa AméricaCrazy TownStella AssangeChelsea ManningYouTubeElon MuskRoberto LuongoAnna Hall (athlete)ICC Men's T20 World CupMckenna GraceStanley CupJJ RedickConn Smythe Trophy.xxxInside Out 2Danny MakkelieZaheer IqbalAfghanistan national cricket teamMoney in the Bank (2024)Gordon Todd SkinnerProject 2025Dr Disrespect