James Gamble may refer to:
- James Gamble (industrialist) (1803–1891), U.S.-based Irish soapmaker and industrialist; co-founder of Procter & Gamble Company
- James Gamble (congressman) (1809–1883), U.S. Representative from Pennsylvania
- James Gamble (telegraph) (18??–?), Piedmont resident, and builder of the first telegraph in California
- James Sykes Gamble (1847–1925), English botanist
- James Fulton Gamble, Northern Irish politician
- James Gamble (1995–2015), Canadian co-conspirator responsible for the Halifax mass shooting plot
This disambiguation page lists articles about people with the same name.
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