List of Billboard Hot 100 number ones of 2001

The Billboard Hot 100 is a chart that ranks the best-performing singles of the United States. Published by Billboard magazine, the data are compiled by Nielsen SoundScan based collectively on each single's weekly physical sales, and airplay. In 2001, there were 14 singles that topped the chart,^[1] in 52 issue dates. Although 15 singles claimed the top position throughout the year, group Destiny's Child's "Independent Women Part I" is credited in 2000, and is thus excluded.^{[citation needed]}

During the year, 12 acts had achieved a first U.S. number-one single, namely: Shaggy, Ricardo "RikRok" Ducent, OutKast, Mystikal, Crazy Town, Rayvon, Lil' Kim, Mýa, Pink, Alicia Keys, Ja Rule, Mary J. Blige, and Nickelback. Destiny's Child, Usher and Shaggy had two number-one singles in 2001.

Janet Jackson's "All for You" is the longest-running single of the year, staying at number one for seven consecutive weeks.^[1] 2001 is the first year since 1993 that there has not been at least one number-one hit with a double-digit run.^[1] "All for You" is also responsible to give to Jackson the tenth Hot 100 number one of her career; making her the fourth female artist with most number ones in the rock era.^[2] Other singles that had a multiple chart run includes Alicia Keys' "Fallin'" and Mary J. Blige's "Family Affair"; both stayed atop for six weeks.^[1]