Estradiol diundecylate/hydroxyprogesterone heptanoate/testosterone cyclohexylpropionate
(Redirected from Trioestrine Retard)
Estradiol diundecylate/hydroxyprogesterone heptanoate/testosterone cyclohexylpropionate (EDU/OHPH/TCHP), sold under the brand name Trioestrine Retard, is an injectable combination medication of estradiol diundecylate (EDU), an estrogen, hydroxyprogesterone heptanoate (OHPH), a progestogen, and testosterone cyclohexylpropionate (TCHP), an androgen/anabolic steroid.[1][2][3] It contained 2.25 mg EDU, 100 mg OHPH, and 67.5 mg TCHP in oil solution, was provided as ampoules, and was administered by intramuscular injection.[1][2][3][4][5] The medication was manufactured by Roussel and Théramex and was marketed by 1953.[6] It is no longer available.[7][8]
Combination of | |
---|---|
Estradiol diundecylate | Estrogen |
Hydroxyprogesterone heptanoate | Progestogen |
Testosterone cyclohexylpropionate | Androgen; Anabolic steroid |
Clinical data | |
Trade names | Trioestrine Retard |
Other names | EDU/OHPH/TCHP |
Routes of administration | Intramuscular injection |
See also
editReferences
edit- ^ a b Herschberg AD (October 1960). "[The menopause and the treatment of its disorders by a long-acting multihormone complex: trioestrine lente]". Gazette Médicale de France (in French). 67: 1987–1996. PMID 13713782.
- ^ a b Krówczyński L (1987). Extended Release Dosage Forms. CRC Press. p. 13. ISBN 978-0-8493-4307-0.
Hydroxyprogesterone heptanoate + testosterone cyclohexylpropionate + oestradiol undecanoate. Trioestrine-RetardR (Theramex). Oily solution for injection.
- ^ a b Kleemann A, Engel J (2001). Pharmaceutical substances: syntheses, patents, applications. Thieme. p. 1998. ISBN 978-3-13-558404-1.
- ^ Bordier, Philippe (1963). "Cure of fifteen osteoporosis cases by a delayed effect of hormonal association". Semaine des Hopitaux. 39 (2): 81–4. ISSN 0037-1777.
The patients (females) received intramuscularly, every 10 days for 2-3 months, estradiol diundecyleate 2.25, testosterone cyclohexylpropionate 67.5, and hydroxyprogesterone heptylate 100 mg. ("trioestrine retard"). Their av. calcuria decreased 30.5% (0-69%) and asthenia, anorexia, and muscular activity improved.
- ^ France (1964). Journal officiel de la République française.
Spécialité dénommée Trioestrine retard Theramex, soluté injectable I. M. : [...] Composition : heptylate d'hydroxy-17 alpha-progestérone, 10 g ; cyclohexyl propionate de testostérone, 10 g ; di-undécylate d'œstradiol, 0,5 g ; excipient Q. S. P. 100 ml (en boîtes de 2 ampoules de 1 ml).
- ^ France (March 1953). Journal officiel de la République française. pp. 2564–.
- ^ "Home". micromedexsolutions.com.
- ^ "Trioestrine". Drugs.com.[permanent dead link]
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