Receptorium dopaminae D2

Receptorium dopaminae D2 cum scientiae abbreviatura DR2 est proteinum et in cerebro receptorium principale industriarum substantiarum antipsychoticarum. In hominibus in chromosomate 11 (11q23.2) locati geni nomen est DRD2^[1]. Nonnullae mutationes adhuc notae sunt.

Natura physiologica

Post receptorii dopaminae D₂ stimulationem intra cellulam synthesis cAMP inhibitur. Receptorium dopaminae D₂ duae formae exstat, altera enim longa, D_2L, altera stricta, D_2S. Ambae formae geno D2D legunter, sed forma D_2L breviori undetriginta acidis aminicis ligamentuculum intracellulare tertium longiore est^[2]. Adhuc ligandi utraeque formae non sunt.

Receptorii dopaminae D₂ affinitates ligandorum

Exempli sunt:

Substantia ligandus	Codex ATC	D₂ K_i (nM)^[3]	D_2L K_i (nM)	D_2S K_i (nM)	Annotatio
Haloperidolum	N05AD01	1.55
Melperonum	N05AD03	194
Norquetiapinum	N05AH04	196			Norquetiapinum est metabolitus Quetiapini
Risperidonum	N05AX08	3.57	4.16	4.73
Amitriptylinum	N06AA09	196–1,460
Nortriptylinum	N06AA10	2,570			Nortriptylinum est metabolitus Amitriptylini

Notae

↑ Descriptio locus geni DRD2 https://web.archive.org/web/20170817021304/http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3023
↑ Xu R, Hranilovic D, Fetsko LA, Bucan M, Wang Y (oct 2002). "Dopamine D2S and D2L receptors may differentially contribute to the actions of antipsychotic and psychotic agents in mice". Mol Psychiatr 7: 1075-82
↑ PDSP.

Nexus interni

[1] Descriptio locus geni DRD2 https://web.archive.org/web/20170817021304/http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3023

[2] Xu R, Hranilovic D, Fetsko LA, Bucan M, Wang Y (oct 2002). "Dopamine D2S and D2L receptors may differentially contribute to the actions of antipsychotic and psychotic agents in mice". Mol Psychiatr 7: 1075-82

[3] PDSP.

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[2]

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Receptorium dopaminae D2

Natura physiologica

Receptorii dopaminae D2 affinitates ligandorum

Notae

Nexus interni

Receptorii dopaminae D₂ affinitates ligandorum